Similar results were observed in other time points from day 2 through day 6. − 2.4 point difference: − 2.75, meeting criteria for superiority). ResultsĬhange of BCSS score in Hydrogen/oxygen group was larger than that in Oxygen group (− 5.3 vs. Adverse events (AEs) were recorded to evaluate safety. Primary endpoint was the change from baseline in BCSS score at day 7. Eligible patients were randomly assigned (in a 1:1 ratio) to receive either hydrogen/oxygen mixture or oxygen therapy. This prospective, randomized, double-blind, controlled clinical trial in 10 centres enrolled patient with AECOPD and a Breathlessness, Cough, and Sputum Scale (BCSS) score of at least 6 points. To investigate whether the administration of hydrogen/oxygen mixture was superior to oxygen in improving symptoms in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).
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